期刊
ACS CHEMICAL NEUROSCIENCE
卷 9, 期 9, 页码 2146-2161出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.7b00508
关键词
Arachidonoylethanolamine; 2-arachidonoylglycerol; cannabinoid receptors; depolarization-induced suppression of inhibition; depolarization-induced suppression of excitation; long-term depression; long-term potentiation
资金
- Division of Intramural Clinical and Biological Research of the National Institute on Alcohol Abuse and Alcoholism [ZIA AA000416 12]
The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.
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