期刊
BIOMEDICAL REPORTS
卷 5, 期 3, 页码 296-300出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2016.725
关键词
extracellular vesicle; microRNAs; skeletal muscle
资金
- National Natural Science Foundation of China [31302049]
- Doctoral Program of Higher Education [20131403120002]
- Agro-scientific Research in the Public Interest [201303119]
Skeletal muscle function is important for good health and independent living, and has been subject to numerous studies focused on skeletal muscle development, function and metabolism. However, progressive and degenerative changes in skeletal muscle function often occur following physiological and pathological stress, and these lead to the progression of diabetes, obesity, chronic kidney disease, and cardiovascular or respiratory diseases. Identifying the mechanisms that influence the processes regulating skeletal muscle function is a key priority. Recently, studies have demonstrated that microRNAs (miRNAs) play important roles in regulating biological processes. For instance, exosomes are key tools for communication between cells. Therefore, by determining how select miRNAs are transported to target organs and initiate their effects, these results will help explain muscle and organ crosstalk, improve our understanding and application of current therapeutic approaches and lead to the identification of new therapeutic strategies and targets aimed at maintaining and/or improving skeletal muscle health.
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