期刊
ACS CHEMICAL BIOLOGY
卷 13, 期 7, 页码 1838-1843出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.8b00099
关键词
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资金
- Alfred P. Sloan Fellowship [FG-2017-8964]
- School of Chemical Sciences NMR Lab by the Roy J. Carver Charitable Trust [15-4521]
- National Science Foundation, Division of Biological Infrastructure [DBI-0100085]
Hypoxia results when the oxygen supply to rapidly growing tumors becomes inadequate to support various physiological processes. This plays a role in tumor metastasis and treatment resistance. Therefore, identifying tumor hypoxia can guide treatment planning and predict patient responses. However, hypoxic volumes are heterogeneously dispersed throughout a tumor, making it a challenge to pinpoint them with any degree of accuracy. Herein, we report the development of ratiometric hypoxia probe 1 (rHyP-1), which is a hypoxia-responsive small-molecule probe designed for reliable hypoxia detection using photoacoustic imaging. Photoacoustic imaging utilizes near-infrared (NIR) light to induce the production of ultrasound signals, enabling high-resolution image acquisition at centimeter depths. Together with the ratiometric capability of rHyP-1, reliable hypoxia detection with unprecedented spatial resolution is possible while minimizing error associated with concentration dependence and tissue heterogeneity.
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