期刊
ACS CHEMICAL BIOLOGY
卷 13, 期 2, 页码 326-332出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.7b00778
关键词
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资金
- National Institutes of Health [UM1HG009408]
- NHGRI [1F30HG009479]
- National Science Foundation
- NIH [5T32HG000035]
Enhancers control the spatiotemporal expression of genes and are essential for encoding differentiation and development. Since their discovery more than three decades ago, researchers have largely studied enhancers removed from their genomic context. The recent adaptation of CRISPR/Cas9 to genome editing in higher organisms now allows researchers to perturb and test these elements in their genomic context, through both mutation and epigenetic modulation. In this Perspective, we discuss recent advances in scanning noncoding regions of the genome for enhancer activity using CRISPR-based tools.
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