期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 2, 页码 1605-1615出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b17838
关键词
bismuth nanoparticles; photothermal therapy; computed tomography imaging; photoacoustic imaging; core-shell structure
资金
- National Natural Science Foundation of China [21473045, 51401066]
- Fundamental Research Funds from the Central University [PIRSOF HIT A201503]
- State Key Laboratory of Urban Water Resource and Environment, the Harbin Institute of Technology [2018DX04]
High-performance theranostic nanoagents, which integrate multi-modal imaging and photothermal therapy for clinical anticancer treatment, are highly desired. Herein, we report the synthesis and bioapplication of a multifunctional theranostic nanoagent based on polyethylene glycol (PEG)-modified polypyrrole (PPy)-coated bismuth (Bi) nanohybrids (referred to as Bi@PPy-PEG NHs) for X-ray computed tomography/photoacoustic (CT/PA) dual-modal imaging and photothermal therapy (PTT). The obtained Bi@PPy-PEG NHs have a distinct core-shell structure with the metallic Bi nanoparticle as the inner core and the PPy-PEG layer as the shell. The Bi@PPy-PEG NHs show excellent physiological stability and compatibility, without noticeable cytotoxicity. Importantly, the NHs exhibit strong NIR absorbance and remarkable photothermal conversion capability and conversion stability, with the photothermal conversion efficiency as high as similar to 46.3%. Thanks to the strong PTT effect, highly effective photothermal ablation on cancer cells has been achieved both in vitro and in vivo. Furthermore, a high-contrast in vitro and in vivo CT/PA dual-modal imaging has been realized, showing great potential to provide comprehensive diagnosis information for antitumor treatment. In particular, the CT enhancement efficiency of the NHs is of similar to 14.4 HU mM(-1), which is similar to 3.7-fold that of clinically used iohexol. Therefore, our work highlights the potential of using such core-shell Bi@PPy-PEG NHs as a versatile theranostic nanoplatform for cancer imaging and therapy.
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