期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 24, 页码 20790-20800出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b05063
关键词
near-infrared light-responsive nanovector; polymers; upconversion nanoparticles; UV-labile polyelectrolyte; drug release
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- le Fonds de recherche du Quebec: Nature et technologies (FRQNT)
- National Key Research and Development Program of China [2017YFC0107400, 2017YFC0107401]
- National Natural Science Foundation of China [21674022, 51703034]
- FRQNT
- China Scholarship Council (CSC)
A new approach to encapsulating charged cargo molecules into a nanovector and subsequently using near-infrared (NIR) light to trigger the release is demonstrated. NIR light-responsive nanovector was prepared through electrostatic interaction-driven complexation between negatively charged silica-coated upconversion nanoparticles (UCNP@silica, 87 nm hydrodynamic diameter, polydispersity index similar to 0.05) and a positively charged UV-labile polyelectrolyte bearing pendants of poly(ethylene glycol) and o-nitrobenzyl side groups; whereas charged fluorescein (FLU) was loaded through a co-complexation process. By controlling the amount of polyelectrolyte, UCNP@silica can be covered by the polymer, whereas remaining dispersed in aqueous solution. Under 980 nm laser excitation, UV light emitted by UCNP is absorbed by photolytic side groups within polyelectrolyte, which results in cleavage of o-nitrobenzyl groups and formation of carboxylic acid groups. Such NIR light-induced partial reversal of positive charge to negative charge on the polyelectrolyte layer disrupts the equilibrium among UCNP@silica, polyelectrolyte, and FLU and, consequently, leads to release of FLU molecules.
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