期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 23, 页码 19386-19397出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b03008
关键词
mesoporous carbon; thermosensitive; liposome; photothermal therapy; chemotherapy; synergistic
资金
- National Natural Science Foundation of China [81603058, 81473165]
- China Postdoctoral Science Foundation [2017M611270]
- Career Development Program for Young Teachers in Shenyang Pharmaceutical University [ZQN2016025]
- Liaoning Provincial Key Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department [LZ2015068]
Thermochemotherapy exhibits a synergistic therapeutic efficiency for cancer, and the sensitivity of cancer cells to chemical drugs could be increased to a large extent at elevated temperature. In this work, a biocompatible nanocomposite thermosensitive mesoporous carbon nanoparticles (TSMCN) was prepared by covering a liposome on mesoporous carbon nanoparticles (MCN). The TSMCN had good photothermal efficiency and photostability. The doxorubicin (DOX)-loaded TSMCN (DOX/TSMCN) showed a slower release than the DOX-loaded MCN-COOH (DOX/MCN-COOH) both in simulated tumor environment and physiological environment. And release curves of DOX/TSMCN exposed to NIR laser exhibited the fast release property. The confocal laser scanning microscopy results illustrated that cellular uptake of DOX for DOX/TSMCN can be enhanced by NIR laser. The temperature of the tumor site reached up to 51.9 degrees C within 3 min after exposure to laser at 1.25 W/cm(2) power density, which is above the phase transition temperature (Tm) of liposome (40.7 degrees C). The biodistribution of DOX in vivo indicated that NIR laser can prolong the retardation time of DOX in the tumor site. The results of both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and antitumor efficiency elucidated that the DOX/TSMCN under NIR irradiation had a synergistic therapeutic effect for cancer. Thus, the TSMCN could be explored as a powerful nanoplatform that shows great prospect in thermochemotherapy of tumor therapy
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