期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 4, 页码 3210-3218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b13782
关键词
phenylboronic acid; gold nanocluster; fluorescence; point-of-care; smartphone device; mucin; sialic acid; anticancer
资金
- Department of Biotechnology Government of India
- Department of Electronics and Information Technology Government of India [5(9)/2012-NANO (Vol. II)]
- Department of Biotechnology, Government of India [BT/PR13560/COE/34/44/2015, DBT-NER/Health/47/2015]
A phenylboronic acid templated gold nanocluster probe was developed to detect biomarker mucin by a noninvasive fluorescence based method using a point-of-care smartphone-based fluorescence detection device. The gold nanocluster probe is able to detect mucin specifically. The same probe was applied for in vitro targeted bioimaging of HeLa and Hep G2 cancer cells, and it demonstrated specific therapeutic effects toward cancer cells as well as multicellular tumor spheroids imparting theranostic properties. The module is found to be more effective toward HeLa cells, and a pathway of cell death was established using flow-cytometry-based assays.
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