期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 8, 页码 6991-7002出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b00112
关键词
photodynamic therapy; plasmonic resonance energy transfer; core-shell structure; self-enriched oxygen; peifluorocarbon
资金
- Special Foundation for State Major Research Program of China [2016YFC0106602, 2016YFC0106601]
- National Natural Science Foundation of China [21645005, 21475008]
- Open Research Fund Program of Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University [PRRD-2016-YB2]
Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu2O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu2O, Au@SiO2@Cu2O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.
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