期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 15, 页码 13226-13235出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b01550
关键词
plasmonic cavity; small molecule detection; plasmonic detection platform; plasmonic resonance energy transfer (PRET); surface-enhanced Raman scattering (SERS)
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1A2B4003267, NRF-2014R1A1A1038069]
- Mid-Career Researcher Support Program through the National Research Foundation of Korea - Ministry of Science, ICT, and Future Planning [2016R1A2B3014157]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science, ICT, and Future Planning [2016R1A6A1A03012845]
- National Research Foundation of Korea [2016R1A2B3014157] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Owing to its high sensitivity and high selectivity along with rapid response time, plasmonic detection has gained considerable interest in a wide variety of sensing applications. To improve the fieldwork applicability and reliability of plasmonic detection, the integration of plasmonic nano particles into optical devices is desirable. Herein, we propose an integrated label-free detection platform comprising a plasmonic cavity that allows sensitive molecular detection via either surface-enhanced Raman scattering (SERS) or plasmon resonance energy transfer (PRET). A small droplet of metal ion solution spontaneously produces a plasmonic cavity on the surface of uncured poly(dimethylsiloxane) (PDMS), and as PDMS is cured, the metal ions are reduced to form a plasmonic antennae array on the cavity surface. Unique spherical feature and the integrated metallic nanoparticles of the cavity provide excellent optical functions to focus the incident light in the cavity and to rescatter the light absorbed by the nanoparticles. The optical properties of the plasmonic cavity for SERS or PRET are optimized by controlling the composition, size, and density of the metal nanoparticles. By using the cavity, we accomplish both 1000-fold sensitive detection and real-time monitoring of reactive oxygen species secreted by live cells via PRET. In addition, we achieve sensitive detection of trace amounts of toxic environmental molecules such as 5-diloro-2-methyl-4-isothiazolin-3-one/2-methyl-4-isothiazol-3-one (CMIT/MIT) and bisphenol A, as well as several small biomolecules such as glucose, adenine, and tryptophan, via SERS.
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