4.8 Article

Engineered Phage Matrix Stiffness-Modulating Osteogenic Differentiation

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 5, 页码 4349-4358

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b17871

关键词

phage; matrix; stiffness; osteogenic; differentiation

资金

  1. Korea Health Industry Development Institute (KHIDI) - Ministry of Health AMP
  2. Welfare, Republic of Korea [HI16C1067]
  3. National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1D1A1B03935221]

向作者/读者索取更多资源

Herein, we demonstrate an engineered phage mediated rmatrix for osteogenic differentiation with controlled stiffness by cross-linking the engineered, phage displaying Arg-Gly-Asp (RGD) and His-Pro-Gln (HPQ) with various Concentrations of streptavidin or polymer, poly(diallyldirnethylammonium)chltiride (PDDA). Osteogenic gene expressions showed that they were specifically increased when MC3T3 cells were cultured, on the stiffer phage matrix than the softer one. Our phage matrixes can be easily functionalized using chemical/gerietic engineering and-Used as a stem cell tissue matrix stiffness platform for modulating differential cell expansion and differentiation.

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