期刊
RSC ADVANCES
卷 6, 期 74, 页码 70117-70123出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra11152a
关键词
-
资金
- National Natural Science Foundation of China [21575154, 21275156]
A cyanine dye-dimethylindole red containing an extending polymethine chain, a sterically bulky dimethylindole heterocycle and an anionic propylsulfonate substituent on the quinoline ring was found to behave as a high specific light-up G-quadruplex probe in the red-emitting region above 650 nm, especially for parallel G-quadruplex c-myc. The 10 to 70-fold enhancement in the fluorescence quantum yield of dimethylindole red when incubating with G-quadruplexes may benefit more accurate definition of the distribution of G-quadruplexes across the genome.
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