期刊
AAPS PHARMSCITECH
卷 19, 期 6, 页码 2672-2678出版社
SPRINGER
DOI: 10.1208/s12249-018-1099-8
关键词
pentyl gallate; nanoemulsion; hydrogel
The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n-alkyl ester, through the skin. PG is an antioxidant agent; however, it seems to be a promising agent for herpis labialis treatment. Aristoflex AVC(A (R)) and chitosan were used as gelling agents for nanoemulsion thickening. The developed formulations presented suitable PG content (94.4-100.3% w/w), nanometric droplet sizes (162-297 nm), high zeta potentials, and a non-Newtonian pseudoplastic behavior. Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8A degrees C during 3 months of storage.
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