期刊
AAPS JOURNAL
卷 20, 期 3, 页码 -出版社
SPRINGER
DOI: 10.1208/s12248-018-0211-z
关键词
Apoptotic bodies; Engineered exosomes; Exosomes; Extracellular vesicles; Microvesicles
资金
- NIH [K08 HL130594]
- Harold Brody Clinical Translational Research Award
Extracellular vesicles (EVs) comprise a heterogeneous group of small membrane vesicles, including exosomes, which play a critical role in intracellular communication and regulation of numerous physiological processes in health and disease. Naturally released from virtually all cells, these vesicles contain an array of nucleic acids, lipids and proteins which they transfer to target cells within their local milieu and systemically. They have been proposed as a means of cell-free, cell therapy for cancer, immune disorders, and more recently cardiovascular disease. In addition, their unique properties of stability, biocompatibility, and low immunogenicity have prompted research into their potential as therapeutic delivery agents for drugs and small molecules. In this review, we aim to provide a comprehensive overview of the current understanding of extracellular vesicle biology as well as engineering strategies in play to improve their therapeutic potential.
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