期刊
NATURE REVIEWS CHEMISTRY
卷 1, 期 5, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41570-017-0035
关键词
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资金
- European Research Council under the Seventh Framework Programme of the European Community (ERC) [338912]
- Sir Michael and Lady Sobell Academic Chair
Metal-catalysed functionalization of a carbon-hydrogen bond can occur selectively even in the presence of ostensibly more reactive functional groups. Such conversions have changed our perceptions of organic chemistry because we can now consider a C-H bond as a functional group, the reactions of which are among the most attractive and powerful means to rapidly add complexity. Another versatile tool in organic synthesis is the metal-catalysed selective cleavage of C-C bonds. Applying both expedient methods in a tandem process would give us an ideal approach to synthesizing complex molecular architectures. The challenge lies in ensuring that the reactions do not interfere with each other; the simultaneous control of both C-H and C-C bond activations is the subject of this Review. The reactions that meet this challenge and enable a selective merger of C-H and C-C bond activations in a one-pot process are discussed. Their realization could afford sophisticated molecular fragments that are otherwise difficult to access.
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