期刊
NATURE ECOLOGY & EVOLUTION
卷 1, 期 8, 页码 1074-1083出版社
NATURE PORTFOLIO
DOI: 10.1038/s41559-017-0229-0
关键词
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资金
- NIH [R21-AG049936, 1R01GM102562]
- NSF [BCS-1455808]
- NIH from the Training, Workforce Development and Diversity division of the National Institute of General Medical Sciences [K12GM000678]
Genome-scale bisulfite sequencing approaches have opened the door to ecological and evolutionary studies of DNA methylation in many organisms. These approaches can be powerful. However, they introduce new methodological and statistical considerations, some of which are particularly relevant to non-model systems. Here, we highlight how these considerations influence a study's power to link methylation variation with a predictor variable of interest. Relative to current practice, we argue that sample sizes will need to increase to provide robust insights. We also provide recommendations for overcoming common challenges and an R Shiny app to aid in study design.
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