期刊
NATURE BIOMEDICAL ENGINEERING
卷 1, 期 4, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41551-017-0056
关键词
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资金
- US National Institutes of Health (NIH) [5-U54-CA151884, P01-CA080124, R35 CA197743, P50 CA165962, R01-CA126642, R01-CA096915]
- NIH [4-P41-EB015871-30, DP3-DK101024 01, 1-U01-NS090438-01, 1-R01-EY017656 -0, 6A1, 1-R01-HL121386-01A1]
- US National Cancer Institute/Federal Share Proton Beam Program Income
- US National Foundation for Cancer Research
- Warshaw Institute for Pancreatic Cancer Research
- Massachusetts General Hospital Executive Committee on Research
- US Army Research Office through the Institute for Soldier Nanotechnologies [W911NF-13-D-0001]
- US Department of Defence through DoD [W81XWH-10-1-0016]
- US National Science Foundation (NSF) [ECCS-1449291]
- Massachusetts Institute of Technology (MIT) Center for Excitonics, an Energy Frontier Research Center - US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001088]
- European Molecular Biology Organization long-term fellowship
- Deutsche Forschungsgemeinschaft Research Fellowship [BA 4925/1-1]
- Evonik Stiftung
- Boehringer Ingelheim Fonds
- National Defence Science and Engineering Graduate Fellowship [32 CFR 168a]
- Fondation Leducq-Triglyceride Metabolism in Obesity and Cardiovascular Disease
- Mildred Scheel Fellowship
- NSF GRFP fellowships
- Deutsche Forschungsgemeinschaft
- SolidarImmun Foundation
- Biosym IRG of Singapore-MIT Alliance Research and Technology Center
- Koch Institute for Integrative Cancer Research Bridge Initiative
- Hamamatsu Inc.
- Samsung GRO program
- Air Force Office of Scientific Research
- US Department of Defence
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1449291] Funding Source: National Science Foundation
For in vivo imaging, the short-wavelength infrared region (SWIR; 1,000-2,000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolour imaging and fast acquisition speed afforded by the SWIR quantum dots, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.
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