期刊
NATURE REVIEWS IMMUNOLOGY
卷 16, 期 10, 页码 612-625出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2016.94
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资金
- National Natural Science Foundation of China [81330070]
- National Natural Science Funds for Distinguished Young Scholar [81425011]
T follicular helper (T-FH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells. TFH cells exhibit unique molecular, cellular and tissue-dynamic features that are integral to their development and function but that are not necessarily compatible with the classical paradigm of effector CD4(+) T cell differentiation. Here, I discuss recent advances in TFH cell biology and their implications for our understanding of T cell differentiation and memory in humoral immunity from spatiotemporal and functional perspectives.
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