期刊
NATURE REVIEWS IMMUNOLOGY
卷 16, 期 10, 页码 500-611出版社
NATURE PORTFOLIO
DOI: 10.1038/nri.2016.80
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资金
- Ludwig Cancer Research
- Cancer Research Institute
- Wilhelm Sander Foundation
- Swiss Cancer Research [3507-09-2014]
- Swiss National Science Foundation [CRSII3_141879, 320030_152856]
- Novartis Foundation for medical-biological Research
- Melanoma Research Alliance
- Harry J. Lloyd Charitable Trust
- SwissTransMed [KIP 18]
- Swiss National Science Foundation (SNF) [320030_152856] Funding Source: Swiss National Science Foundation (SNF)
Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the basis of similarities to dysfunctional T cells in chronic infections. However, despite shared properties, recent studies have identified marked differences between T cell dysfunction in cancer and chronic infection. In this Review, we discuss T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.
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