期刊
CANNABIS AND CANNABINOID RESEARCH
卷 1, 期 1, 页码 229-233出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/can.2016.0026
关键词
cannabis; cues; age of onset; early onset; craving
资金
- Pennsylvania Department of Health Commonwealth Universal Research Enhancement grant
- National Institutes of Health [U54DA039002, R01DA040670, K23AA023894]
Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use-changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) cannabis users versus late-onset (LOs) cannabis users might exhibit, respectively, greater dorsal versus ventral striatal response to drug cues. We used functional magnetic resonance imaging and an event-related blood oxygen level-dependent backward-masking task to evaluate striatal responses to backward-masked cannabis cues (vs. neutral cues) in EOs (<16 years old, n=15) and LOs (>= 16 years old, n=26) with similar recent cannabis use patterns. Direct comparisons revealed that EOs showed greater response to cannabis cues in the dorsal striatum than LOs (p0.01, k50 voxels). Within-group analyses revealed that EOs showed greater neural response to cannabis cues in the dorsal striatum, whereas LOs exhibited greater neural response to cannabis cues in the ventral striatum. Although cross-sectional, these findings are consistent with recent addiction theories suggesting a progressive shift from ventral to dorsal striatal control over drug-seeking behavior and highlight the importance of age of onset of cannabis use on the brain and cognition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据