期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 103, 期 1, 页码 107-114出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.115.115105
关键词
breastfeeding; infants; vitamin D; nutrition; rickets
资金
- Aase og Ejnar Danielsens fund
Background: Parents are advised to avoid the direct sun exposure of their newborns. Therefore, the vitamin D status of exclusively breastfed newborns is entirely dependent on the supply of vitamin D from breast milk. Objectives: We explored concentrations of ergocalciferol (vitamin D-2) and cholecalciferol (vitamin D-3) (vitamin D) and 25-hydroxivitamin D-2 plus D-3 (25-hydroxyvitamin D [25(OH)D]) in foremilk and hindmilk during the first 9 mo of lactation and identified indexes of importance to the concentrations. Design: We collected blood and breast-milk samples from mothers at 2 wk (n = 107), 4 mo, (n = 90), and 9 mo (n = 48) postpartum. Blood samples from infants were collected 4 and 9 mo after birth. We measured concentrations of vitamin D metabolites in blood and milk samples with the use of liquid chromatography tandem mass spectrometry. Results: Concentrations of vitamin D and 25(OH)D correlated significantly and were higher in hindmilk than in foremilk. Milk concentrations were also correlated with maternal plasma 25(OH)D concentrations. In foremilk and hindmilk, concentrations were a median (IQR) of 1.35% (1.04-1.84%) and 2.10% (1.63-2.65%), respectively, of maternal plasma 25(OH)D concentrations (P < 0.01). Milk concentrations showed a significant seasonal variation. Mothers who were taking vitamin D supplements had higher concentrations than did nonusers. Medians (IQRs) of infant daily intake through breast milk of vitamin D and 25(OH)D were 0.10 mu g (0.02-0.40 mu g) and 0.34 mu g (0.24-0.47 mu g), respectively, which were equal to a median (IQR) antirachitic activity of 77 IU/d (52-110 IU/d). Conclusions: The supply of vitamin D from breast milk is limited. Exclusively breastfed infants received <20% of the daily dose recommended by the Institute of Medicine for infants during the first year of life. This trial was registered at clinicaltrials.gov as NCT02548520.
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