期刊
FRONTIERS IN MATERIALS
卷 4, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmats.2017.00045
关键词
glioblastoma; invasion; in vitro three-dimensional model; microenvironment; biomimetic scaffolds
资金
- National Research Foundation of Korea (NRF) [NRF-2015H1A2A1030560, NRF-2016R1E1A1A01943393]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C1324]
- Ministry of Science ICT and Future Planning, Republic of Korea [2016M3A9B4915823]
- National Research Foundation of Korea [2016M3A9B4915823, 2015H1A2A1030560] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence. Most therapies for GBM have focused on the cytotoxicity and have not targeted GBM spread. However, there have been numerous attempts to improve therapy by addressing GBM invasion, through understanding and mimicking its behavior using three-dimensional (3D) experimental models. Compared with two-dimensional models and in vivo animal models, 3D GBM models can capture the invasive motility of glioma cells within a 3D environment comprising many cellular and non-cellular components. Based on tissue engineering techniques, GBM invasion has been investigated within a biologically relevant environment, from biophysical and biochemical perspectives, to clarify the pro-invasive factors of GBM. This review discusses the recent progress in techniques for modeling the micro-environments of GBM tissue and suggests future directions with respect to recreating the GBM microenvironment and preclinical applications.
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