期刊
VIROLOGICA SINICA
卷 32, 期 6, 页码 454-464出版社
SPRINGER
DOI: 10.1007/s12250-017-4009-4
关键词
hepatitis B virus (HBV); covalently closed circular DNA (cccDNA); HBx; immune-mediated; genome-editing nucleases
类别
资金
- Hubei Province Natural Science Foundation [2014CFA075]
- National Natural Science Foundation of China [31400153]
- Applied Basic Research Program, Wuhan, China [2015060101010033]
Chronic hepatitis B infection is caused by hepatitis B virus (HBV) and a total cure is yet to be achieved. The viral covalently closed circular DNA (cccDNA) is the key to establish a persistent infection within hepatocytes. Current antiviral strategies have no effect on the pre-existing cccDNA reservoir. Therefore, the study of the molecular mechanism of cccDNA formation is becoming a major focus of HBV research. This review summarizes the current advances in cccDNA molecular biology and the latest studies on the elimination or inactivation of cccDNA, including three major areas: (1) epigenetic regulation of cccDNA by HBV X protein, (2) immune-mediated degradation, and (3) genome-editing nucleases. All these aspects provide clues on how to finally attain a cure for chronic hepatitis B infection.
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