期刊
IMMUNE NETWORK
卷 17, 期 2, 页码 77-88出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2017.17.2.77
关键词
Mitochondria; Inflammation; Innate immunity; Autophagy; Inflammasome
类别
资金
- research fund of Chungnam National University
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [NRF-2015M3C9A2054326]
Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform regulating innate immune and inflammatory responses. Several mitochondrial proteins and mitochondrial reactive oxygen species have emerged as central players orchestrating the innate immune responses to pathogens and damaging ligands. This review explores our current understanding of the roles played by mitochondria in regulation of innate immunity and inflammatory responses. Recent advances in our understanding of the relationship between autophagy, mitochondria, and inflammasome activation are also briefly discussed. A comprehensive understanding of mitochondrial role in toll-like receptor-mediated innate immune responses and NLRP3 inflammasome complex activation, will facilitate development of novel therapeutics to treat various infectious, inflammatory, and autoimmune disorders.
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