期刊
JOURNAL OF CHEMICAL SCIENCES
卷 128, 期 9, 页码 1445-1449出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-016-1154-5
关键词
Triazole; benzotriazinone; diazonium chemistry; nanocatalyst; acetylcholinesterase
资金
- Research Council of Tehran University of Medical Sciences (TUMS)
- Iran National Science Foundation (INSF)
- [93-03-45-29092]
An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman's method.
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