期刊
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 2015, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2015/235491
关键词
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资金
- Key Science and Technology Innovation Team of Zhejiang Province [2013TD15]
- National Nature Science Foundation of China [81574056]
- Traditional Chinese Medicine of Zhejiang Province Outstanding Young Talent Fund Plan [2013ZQ017]
- Zhejiang Provincial Natural Science Found of China [LY15H270009]
- Young and Middle-Aged Discipline Leaders of Institutions of Higher Learning in Zhejiang Province [2013203]
- Zhejiang Province Top Key Discipline of Chinese Medicine-Acupuncture Tuina
Persistent neuropathic pain is associated with anxiety. The phosphorylation of extracellular signal-regulated kinase (p-ERK) in the anterior cingulate cortex (ACC) plays an important role in pain-induced anxiety. Acupuncture is widely used for pain and anxiety. However, little is known about which acupuncture technique is optimal on pain-induced anxiety and the relationship between acupuncture effect and p-ERK. The rat model was induced by L5 spinal nerve ligation (SNL). Male adult SD rats were randomly divided into control, SNL, strong manual acupuncture (sMA), mild manual acupuncture (mMA), and electroacupuncture (EA) group. Bilateral Huantiao (GB 30) were stimulated by sMA, mMA, and EA, respectively. The pain withdrawal thresholds (PWTs) and anxiety behavior were measured, and p-ERK protein expression and immunoreactivity cells in ACC were detected. PWTs increased significantly in both sMA and EA groups. Meanwhile, anxiety-like behavior was improved significantly in the sMA and mMA groups. Furthermore, the overexpression of p-ERK induced by SNL was downregulated by strong and mild manual acupuncture. Therefore, strong manual acupuncture on bilateral Huantiao (GB 30) could be a proper therapy relieving both pain and pain-induced anxiety. The effect of different acupuncture techniques on pain-induced anxiety may arise from the regulation of p-ERK in ACC.
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