期刊
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
卷 9, 期 11, 页码 277-294出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1759720X17735756
关键词
anti-interleukin therapy; biologic agents; interleukin; psoriasis
类别
Anti-interleukin (IL) therapies have emerged as a major treatment for patients with moderate-to-severe psoriasis. This article reviews the up-to-date results of pivotal clinical trials targeting the interleukins used for the treatment of psoriasis, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, IL-20, IL-22, IL-23, IL-36 and bispecific biologics IL-17A/tumor necrosis factor alpha (TNF-alpha). Cytokines involved in the circuits of psoriasis inflammation without ongoing clinical trials are also mentioned (IL-9, IL-13, IL-15, IL-16, IL-18, IL-19, IL-21, IL-24, IL-27, IL-33, IL-35, IL-37, and IL-38).
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