期刊
PHARMACEUTICS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics9020016
关键词
mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallisation; non-steroidal anti-inflammatory drugs
资金
- University of Edinburgh
- EastChem, UK
- EPSRC [EP/N015401/1] Funding Source: UKRI
High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules. Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2.5 GPa. No phase transition was observed up to this pressure. A reconstructive phase transition is required to induce conformational changes in the structure, which was confirmed by the results of crystallisation at high pressure.
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