相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Genetically engineered mouse models in oncology research and cancer medicine
Kelly Kersten et al.
EMBO MOLECULAR MEDICINE (2017)
A comprehensive map of molecular drug targets
Rita Santos et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Moritz Schuette et al.
NATURE COMMUNICATIONS (2017)
Data-driven reverse engineering of signaling pathways using ensembles of dynamic models
David Henriques et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks
Fabian Froehlich et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Parameter estimation in large-scale systems biology models: a parallel and self-adaptive cooperative strategy
David R. Penas et al.
BMC BIOINFORMATICS (2017)
Deep learning for computational biology
Christof Angermueller et al.
MOLECULAR SYSTEMS BIOLOGY (2016)
Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges
Chi-Ping Day et al.
CELL (2015)
Time for one-person trials
Nicholas J. Schork
NATURE (2015)
Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack
David Henderson et al.
BIOTECHNOLOGY JOURNAL (2014)
A model reduction method for biochemical reaction networks
Shodhan Rao et al.
BMC SYSTEMS BIOLOGY (2014)
Reverse engineering and identification in systems biology: strategies, perspectives and challenges
Alejandro F. Villaverde et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)
Principles of regulatory information conservation between mouse and human
Yong Cheng et al.
NATURE (2014)
Conservation of trans-acting circuitry during mammalian regulatory evolution
Andrew B. Stergachis et al.
NATURE (2014)
Cancer heterogeneity: implications for targeted therapeutics
R. Fisher et al.
BRITISH JOURNAL OF CANCER (2013)
Tumour heterogeneity and cancer cell plasticity
Corbin E. Meacham et al.
NATURE (2013)
The causes and consequences of genetic heterogeneity in cancer evolution
Rebecca A. Burrell et al.
NATURE (2013)
High-Throughput miRNA and mRNA Sequencing of Paired Colorectal Normal, Tumor and Metastasis Tissues and Bioinformatic Modeling of miRNA-1 Therapeutic Applications
Christina Roehr et al.
PLOS ONE (2013)
Structure and dynamics of molecular networks: A novel paradigm of drug discovery A comprehensive review
Peter Csermely et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Clinical and economic burden of adverse drug reactions
Janet Sultana et al.
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS (2013)
Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches
Martine H. van Miltenburg et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)
Prediction in the face of uncertainty: A Monte Carlo-based approach for systems biology of cancer treatment
Christoph Wierling et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2012)
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Marco Gerlinger et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
M. Gerlinger et al.
BRITISH JOURNAL OF CANCER (2010)
Systems biology: parameter estimation for biochemical models
Maksat Ashyraliyev et al.
FEBS JOURNAL (2009)
Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
Chris Soon Heng Tan et al.
SCIENCE SIGNALING (2009)
Parameter estimation and optimal experimental design
Julio R. Banga et al.
ESSAYS IN BIOCHEMISTRY: SYSTEMS BIOLOGY, VOL 45 (2008)
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman et al.
NATURE BIOTECHNOLOGY (2008)
Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved
Christina Kiel et al.
PLOS COMPUTATIONAL BIOLOGY (2008)
The evolution of signalling pathways in animal development
A Pires-daSilva et al.
NATURE REVIEWS GENETICS (2003)