期刊
FRONTIERS IN ONCOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2017.00139
关键词
mitochondrial calcium uniporter; mitochondrial calcium uniporter pathophysiology; mouse models; breast cancer; mitochondrial calcium uniporter regulators
类别
资金
- Italian Telethon Foundation
- Italian Association for Cancer Research (AIRC)
- Italian Ministry of Education, University, and Research
- French Muscular Dystrophy Association (AFM-Telethon)
- National Institutes of Health (NIH)
Mitochondrial Ca2+ uptake plays a pivotal role both in cell energy balance and in cell fate determination. Studies on the role of mitochondrial Ca2+ signaling in pathophysiology have been favored by the identification of the genes encoding the mitochondrial calcium uniporter (MCU) and its regulatory subunits. Thus, research carried on in the last years on one hand has determined the structure of the MCU complex and its regulation, on the other has uncovered the consequences of dysregulated mitochondrial Ca2+ signaling in cell and tissue homeostasis. Whether mitochondrial Ca2+ uptake can be exploited as a weapon to counteract cancer progression is debated. In this review, we summarize recent research on the molecular structure of the MCU, the regulatory mechanisms that control its activity and its relevance in pathophysiology, focusing in particular on its role in cancer progression.
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