期刊
FRONTIERS IN ONCOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2017.00145
关键词
epithelial-to-mesenchymal transition; adenomyosis; endometriosis; ovarian cancer; endometrial cancer; tumor microenvironment
类别
资金
- Canadian Institutes of Health Research (CIHR) [MOP 89714, MOP 119589, PLS 95381]
- Alberta Cancer Foundation
- Women and Children's Research Institute
- Premier New Investigator Award from the CIHR
- Sawin-Baldwin Chair in Ovarian Cancer AMP
- Dr. Anthony Noujaim Legacy Oncology Chair
- Alberta Innovates Health Solutions Translational Chair in Cancer
- Alberta Innovates [201300495, 201610380] Funding Source: researchfish
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis.
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