期刊
REACTION CHEMISTRY & ENGINEERING
卷 2, 期 6, 页码 919-927出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7re00176b
关键词
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资金
- Austrian COMET Program by the Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT) [862766]
- Austrian Federal Ministry of Science, Research and Economy (BMWFW)
- State of Styria (Styrian Funding Agency SFG)
Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with nBuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, nBuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at -65 degrees C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.
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