期刊
REACTION CHEMISTRY & ENGINEERING
卷 2, 期 3, 页码 295-298出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7re00020k
关键词
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资金
- Syngenta Crop Protection
- EPSRC [EP/K009494/1, EP/M004120/1, EP/K039520/1]
- Engineering and Physical Sciences Research Council [EP/K039520/1, EP/K009494/1, EP/M004120/1] Funding Source: researchfish
- EPSRC [EP/K009494/1, EP/M004120/1, EP/K039520/1] Funding Source: UKRI
A flow chemistry process for the synthesis of 2-substituted cyclobutanones, via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid and mild reaction conditions to access a diverse array of products with good to excellent yield, alongside a good level of functional group compatibility.
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