期刊
CELLS
卷 6, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells6020012
关键词
adenocarcinoma; carcinoma; carcinogenesis; histology; long non-coding RNA; miRNA; molecular pathology; oncology
类别
资金
- JSPS KAKENHI Grant [JP16K08679]
- Ministry of the Environment, Japan
- Grants-in-Aid for Scientific Research [16K08679] Funding Source: KAKEN
Lung cancer is the leading cause of cancer deaths worldwide, yet there remains a lack of specific and sensitive tools for early diagnosis and targeted therapies. High-throughput sequencing techniques revealed that non-coding RNAs (ncRNAs), e.g., microRNAs and long ncRNAs (lncRNAs), represent more than 80% of the transcribed human genome. Emerging evidence suggests that microRNAs and lncRNAs regulate target genes and play an important role in biological processes and signaling pathways in malignancies, including lung cancer. In lung cancer, several tumor suppressor/ oncogenic microRNAs and lncRNAs function as biomarkers for metastasis and prognosis, and thus may serve as therapeutic tools. In this review, recent work on microRNAs and lncRNAs is introduced and briefly summarized with a focus on potential biological and therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据