期刊
SLEEP
卷 40, 期 8, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsx076
关键词
older adults; APOE; genotype; sleep; napping
资金
- Intramural Research Program (IRP), National Institute on Aging (NIA), National Institutes of Health (NIH)
- NIA [R01AG050507]
- William and Ella Owens Medical Research Foundation
- [HHSN-260-2004-00012C]
Study Objectives: The apolipoprotein E (APOE)epsilon 4 allele increases Alzheimer's disease (AD) risk and has been linked to a greater risk of sleep-disordered breathing. We investigated the association of APOE genotype with nonrespiratory sleep parameters. Methods: We studied 1264 cognitively normal participants in the Baltimore Longitudinal Study of Aging (mean = 57.5 +/- 16.1 years, range 19.9-92.0, 48.2% women, 19.8% African American) with APOE genotyping and self-reported sleep duration (>= 9, 7 or 8, <= 6 hours), difficulty falling/staying asleep, and napping. We compared epsilon 4 carriers with all noncarriers and compared persons at reduced (epsilon 2/epsilon 2 or epsilon 2/epsilon 3) or elevated AD risk (>= 1 epsilon 4 allele) with those neutral for AD risk (epsilon 3/epsilon 3). Results: In fully adjusted models, those with >= 1 epsilon 4 allele had a greater odds of being in a shorter sleep duration category compared to all noncarriers (odds ratio [OR] = 1.41, 95% confidence interval [CI] 1.06, 1.88) and epsilon 3/epsilon 3 carriers (OR = 1.43, 95% CI 1.06, 1.92). Compared to epsilon 3/epsilon 3 carriers, epsilon 2/epsilon 2 or epsilon 2/epsilon 3 carriers had a lower odds of reporting napping (OR = 0.64, 95% CI 0.43, 0.96). Among participants aged = 50 years, sleep duration findings remained and.4 carriers had a greater odds of trouble falling/staying asleep than noncarriers (OR = 1.49, 95% CI 1.02, 2.17). We found some evidence for stronger associations of epsilon 4 with sleep duration among African Americans. Conclusions: Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype. Studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据