期刊
CANCERS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers9070093
关键词
pancreatic ductal adenocarcinoma; tumor microenvironment; carcinoma-associated fibroblasts; signaling pathways; immune-suppression and microRNAs
类别
资金
- Interdisciplinary Collaborative Grants
- Comprehensive Cancer Center
- Ohio State University
- University of Maryland School of Medicine and Comprehensive Cancer Center start-up fund
- AACR-Pancreatic Cancer Action Network grant
Pancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquely associated with desmoplastic stroma that accounts for 80% of tumor mass. Understanding the biology of stroma can aid the discovery of innovative strategies for eradicating this lethal cancer in the future. This review highlights the critical components in the stroma and how they interact with the cancer cells to convey the devastating tumor progression.
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