期刊
CANCERS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers9070090
关键词
SIRT3; cancer; ROS; antioxidant enzymes; mitochondria
类别
资金
- Fondo de Investigaciones Sanitarias of Instituto de Salud Carlos III of the Spanish Government [PI14/01434]
- FEDER-Union Europea (Una manera de hacer Europa)
- FPU (Formacion profesorado universitario) grant of Ministerio de Educacion, Cultura y Deporte of Spanish Government
Sirtuin 3 (SIRT3), the major deacetylase in mitochondria, plays a crucial role in modulating oxygen reactive species (ROS) and limiting the oxidative damage in cellular components. SIRT3 targets different enzymes which regulate mitochondrial metabolism and participate in ROS detoxification, such as the complexes of the respiratory chain, the isocitrate dehydrogenase, or the manganese superoxide dismutase. Thus, SIRT3 activity is essential in maintaining mitochondria homeostasis and has recently received great attention, as it is considered a fidelity protein for mitochondrial function. In some types of cancer, SIRT3 functions as a tumoral promoter, since it keeps ROS levels under a certain threshold compatible with cell viability and proliferation. On the contrary, other studies describe SIRT3 as a tumoral suppressor, as SIRT3 could trigger cell death under stress conditions. Thus, SIRT3 could have a dual role in cancer. In this regard, modulation of SIRT3 activity could be a new target to develop more personalized therapies against cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据