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Design and synthesis of a new class of selective integrin α5β1 antagonists
Roland Stragies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A peptide selected by biopanning identifies the integrin αvβ6 as a prognostic biomarker for nonsmall cell lung cancer
Anissa N. Elayadi et al.
CANCER RESEARCH (2007)
HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin αvβ6
Alan G. Ramsay et al.
CANCER RESEARCH (2007)
Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy
Rohit G. Saldanha et al.
JOURNAL OF PROTEOME RESEARCH (2007)
NC-100717: A versatile RGD peptide scaffold for angiogenesis imaging
Bard Indrevoll et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Mechanisms of disease - Cancer stem cells
Craig T. Jordan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Activation of transforming growth factor-β by the integrin αvβ8 delays epithelial wound closure
Claus Neurohr et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin αvβ3 expression in man
Ambros J. Beer et al.
CLINICAL CANCER RESEARCH (2006)
Reciprocal interactions between adhesion receptor signaling and MMP regulation
HG Munshi et al.
CANCER AND METASTASIS REVIEWS (2006)
Targeting RGD recognizing integrins: Drug development, biomaterial research, tumor imaging and targeting
A. Meyer et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression
Michael Stefanidakis et al.
BLOOD (2006)
E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function
F Balzac et al.
JOURNAL OF CELL SCIENCE (2005)
Colorectal cancer progression -: Integrin αvβ6 and the epithelial-mesenchymal transition (EMT)
RC Bates
CELL CYCLE (2005)
An interaction between αvβ8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain
JH McCarty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Integrin αvβ8-mediated activation of transforming growth factor-β by perivascular astrocytes -: An angiogenic control switch
S Cambier et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Noninvasive visualization of the activated αvβ3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
R Haubner et al.
PLOS MEDICINE (2005)
Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
RC Bates et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Integrin-linked kinase: A cancer therapeutic target unique among its ILK
G Hannigan et al.
NATURE REVIEWS CANCER (2005)
Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase
A Oloumi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Integrins: roles in cancer development and as treatment targets
H Jin et al.
BRITISH JOURNAL OF CANCER (2004)
Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour
JD Raguse et al.
ORAL ONCOLOGY (2004)
Integrin signalling during tumour progression
WJ Guo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Immunohistochemical screening for β6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro
B Sipos et al.
HISTOPATHOLOGY (2004)
Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikis
SM Janes et al.
JOURNAL OF CELL BIOLOGY (2004)
Differential expression of matrilysin-1 (MMP-7), 92 kD gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer
U Impola et al.
JOURNAL OF PATHOLOGY (2004)
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9
MR Morgan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Integrin αvβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
JP Annes et al.
JOURNAL OF CELL BIOLOGY (2004)
A computational model of transmembrane integrin clustering
KE Gottschalk et al.
STRUCTURE (2004)
Role of ADMIDAS cation-binding site in ligand recognition by integrin α5β1
AP Mould et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
BD Kelly et al.
CIRCULATION RESEARCH (2003)
ανβ6-Fyn signaling promotes oral cancer progression
XW Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
MJ Reginato et al.
NATURE CELL BIOLOGY (2003)
Integrin αvβ8-mediated activation of transforming growth factor-β inhibits human airway epithelial proliferation in intact bronchial tissue
L Fjellbirkeland et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Ovarian cancer cell proliferation and motility is induced by engagement of integrin αvβ3/vitronectin interaction
S Hapke et al.
BIOLOGICAL CHEMISTRY (2003)
Tumorigenesis and the angiogenic switch
G Bergers et al.
NATURE REVIEWS CANCER (2003)
Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia
LL Nikitenko et al.
FASEB JOURNAL (2003)
αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells
S Cruet-Hennequart et al.
ONCOGENE (2003)
Adhesion and migration of extracellular matrix-stimulated breast cancer
JE Bartsch et al.
JOURNAL OF SURGICAL RESEARCH (2003)
Expression of alpha v integrin family in gastric carcinomas: Increased alpha v beta 6 is associated with lymph node metastasis
A Kawashima et al.
PATHOLOGY RESEARCH AND PRACTICE (2003)
Transmembrane signal transduction of the αIIbβ3 integrin
KE Gottschalk et al.
PROTEIN SCIENCE (2002)
Binding of TGF-β1 latency-associated peptide (LAP) to αvβ6 integrin modulates behaviour of squamous carcinoma cells
GJ Thomas et al.
BRITISH JOURNAL OF CANCER (2002)
Get a ligand, get a life: integrins, signaling and cell survival
DG Stupack et al.
JOURNAL OF CELL SCIENCE (2002)
αvβ6 integrin-A marker for the malignant potential of epithelial ovarian cancer
N Ahmed et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2002)
Integrin expression in colon cancer ells is regulated by the cytoplasmic domain of the β6 integrin subunit
J Niu et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1
DZ Mu et al.
JOURNAL OF CELL BIOLOGY (2002)
Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand
JP Xiong et al.
SCIENCE (2002)
Expression of integrin β6 enhances invasive behavior in oral squamous cell carcinoma
DM Ramos et al.
MATRIX BIOLOGY (2002)
Nanomolar small molecule inhibitors for αvβ6, αvβ5, and αvβ3 integrins
SL Goodman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Overexpression of αvβ6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
N Ahmed et al.
CARCINOGENESIS (2002)
Enhanced pathological angiogenesis in mice lacking beta(3) integrin or beta(3) and beta(5) integrins
LE Reynolds et al.
NATURE MEDICINE (2002)
Integrin-mediated death: An explanation of the integrin-knockout phenotype?
DA Cheresh et al.
NATURE MEDICINE (2002)
Crystal structure of the extracellular segment of integrin αVβ3
JP Xiong et al.
SCIENCE (2001)
The Hedgehog and Wnt signaling pathways in cancer
J Taipale et al.
NATURE (2001)
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
T Teitz et al.
NATURE MEDICINE (2000)
Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin
S Kim et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
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