期刊
CANCERS
卷 9, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cancers9010004
关键词
triple-negative breast cancer; androgen receptor; prognostic marker; individualized treatment; intrinsic subtype
类别
资金
- Ministry of Education, Science, Sports, Culture and Technology of Japan [25461992, 26461957]
- Grants-in-Aid for Scientific Research [17K13225, 25461992, 26461957] Funding Source: KAKEN
Background: Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clinicopathologic features in TNBC. Methods: This study investigated 1036 cases of sporadic invasive breast carcinoma. Immunohistochemical assays were performed to determine the expression of AR in 190 TNBC samples. The relationships between AR expression and clinicopathologic data and prognosis were analyzed. Results: In 190 TNBC cases, the prognosis of AR-positive patients was significantly better (p = 0.019, log-rank) than AR-negative patients, and in multivariate analysis, AR expression was an independent indicator of good prognosis (p = 0.039, hazard ratio = 0.36). In patients with disease relapse, AR positivity was significantly correlated with better prognosis (p = 0.034, log-rank). Conclusions: AR expression may be useful as a subclassification marker for prognosis in TNBC.
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