期刊
JOURNAL OF CLINICAL MEDICINE
卷 6, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/jcm6120112
关键词
MUC5AC; MUC5B; asthma
资金
- NIH [AI077439, HL138424, HL099101]
- Cystic Fibrosis Cell Models Core - NIH grant [DK072517]
- Cystic Fibrosis Cell Models Core - Cystic Fibrosis Foundation [DR613-CR11]
- UCSF Program for Breakthrough Biomedical Research Postdoctoral Independent Research Project Award
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstructiona major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma, and recent work sheds light on their contribution to asthma pathogenesis. Herein, we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.
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