期刊
ACTA PHARMACEUTICA SINICA B
卷 7, 期 3, 页码 334-341出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2017.04.003
关键词
Cruciferac; Isatis indigotica; Indole alkaloid sulfonic acids; Isatibis indosulfonic scids; Isatindosulfonic acids; Antiviral activity
资金
- National Natural Sciences Foundation of China (NNSFC) [81373287, 81630094, 30825044]
Six new indole alkaloid sulfonic acids (1-6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively. (9 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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