期刊
EBIOMEDICINE
卷 26, 期 -, 页码 91-99出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2017.11.009
关键词
Asthma; IgE; Prediction; Rhinitis; Sensitisation
资金
- Swedish Asthma and Allergy Foundation, Stockholm County Council (ALF Medicin), Swedish Research Council
- Swedish Heart-Lung Foundation
- Swedish Cancer and Allergy Foundation
- King Gustaf V 80th Birthday Foundation
- Hesselman Foundation
- Konsul Th C Bergh Foundation
- Magnus Bergvall Foundation
- Working Life and Welfare [F4605]
- European Commission [261357]
- Medical Research Council [MR/M015181/1]
- Medical Research Council [G0601361, MR/K002449/2, MR/K002449/1, MR/M015181/1] Funding Source: researchfish
- MRC [MR/K002449/1, G0601361, MR/K002449/2] Funding Source: UKRI
Background: Sensitization in early childhood may precede respiratory allergy in adolescence. Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16 years. Clinically and independent relevant allergen molecules accounting for >= 90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11 years (N = 248) and the outcome was studied at 11 years. Findings: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to = 3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16 years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16 years were 100% and 100%, respectively, for IgE reactivity to = 3 of 5 risk molecules. Interpretations: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16 years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children. Crown Copyright (C) 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
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