期刊
EBIOMEDICINE
卷 22, 期 -, 页码 242-248出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ebiom.2017.07.021
关键词
OCD; Drug-naive; Pharmacotherapy; Voxel-based morphometry; Cross-validation
资金
- Hundred Talent Program of the Chinese Academy of Sciences (Technology)
- Strategic Priority Research Program (B) of the Chinese Academy of Sciences [XDB02050000]
- National Natural Science Foundation of China [81571300, 81527901, 81271518, 81471387]
Prior efforts to dissect etiological and pharmacological modulations in brain morphology in obsessive-compulsive disorder (OCD) are often undermined bymethodological and sampling constraints, yielding conflicting conclusions and no reliable neuromarkers. Here we evaluated alteration of regional gray matter volume including effect size (Cohen's d value) in 95 drug-naive patients (age range: 18-55) compared to 95 healthy subjects (age: 18-63), then examined pharmacological effects in 65 medicated (age: 18-57) and 73 medication-free patients (age: 18-61). Robustness of statistical outcomes and effect sizes was rigorously tested with Monte Carlo cross-validation. Relative to controls, both drug-naive and medication-free patients exhibited comparable volumetric increasesmainly in the left thalamus (d=0.90, 0.82, respectively), left ventral striatum (d=0.88, 0.67), bilateralmedial orbitofrontal cortex (d=0.86, 0.71; 0.90, 0.73), and left inferior temporal gyrus (d=0.83, 0.66), and decreased volumes in left premotor/presupplementary motor areas (d=-0.83, -0.71). Interestingly, abnormalities in the thalamus and medial orbitofrontal cortex were present in medicated patients whereas entirely absent in premotor and ventral striatum. It suggests that pharmacotherapy elicited divergent responses in orbitofronto-striato-thalamic and premotor circuits, which warrants the design of longitudinal studies investigating the potential of these neuromarkers in stratified treatments of OCD. (C) 2017 The Authors. Published by Elsevier B.V.
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