期刊
GENOMICS PROTEOMICS & BIOINFORMATICS
卷 15, 期 5, 页码 267-278出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gpb.2017.05.002
关键词
RNA structure probing; RNA structurome; RNA secondary structure; Structure-function relationship; RNA regulation
资金
- National Natural Science Foundation of China [31671355]
- National Thousand Young Talents Program of China
RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i. e., RNA structuromes, have been developed. Applications of these approaches to different cell lines and tissues have generated a rich resource for the study of RNA structure-function relationships at a systems biology level. In this review, we first introduce the designs of these methods and their applications to study different RNA structuromes. We emphasize their technological differences especially their unique advantages and caveats. We then summarize the structural insights in RNA functions and regulations obtained from the studies of RNA structuromes. And finally, we propose potential directions for future improvements and studies.
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