期刊
NATURE REVIEWS IMMUNOLOGY
卷 16, 期 11, 页码 676-689出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2016.95
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资金
- Wellcome Trust
- Medical Research Council, UK
- Agence Nationale de la Recherche [ANR-12-BSV3-0005-01]
- Institut National du Cancer (INCA)
- Fondation ARC
- US National Institutes of Health, National Heart, Lung, and Blood Institutes [R01 HL122489]
- National Institute of Allergy and Infectious Diseases [R21 AI121981]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV3-0005] Funding Source: Agence Nationale de la Recherche (ANR)
Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (T(H)2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (T-reg) cells, T(H)1 cells, CD8(+) T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.
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