期刊
CHEMISTRYSELECT
卷 2, 期 16, 页码 4301-4308出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201700885
关键词
Cancer; Click Chemistry; Quinones; Rhodium(II) Azavinyl carbenes; Triazoles
资金
- CNPq [474797/2013-9, PVE 401193/2014-4, PQ 305385/2014-3]
- Chamada Universal MCTI/CNPq [01/2016]
- FAPEMIG [01/2014 APQ-02478-14]
- CAPES
- INCT-Catalise
- CAPES [99999.008126/2015-01]
- DAAD [99999.008126/2015-01]
Quinone-based N-sulfonyl-1,2,3-triazoles were synthesized by click chemistry and subsequently evaluated against eight types of cancer cell lines. Some of the compounds exhibited potent cytotoxicity with IC50 values < 1.0 mu M. Also, the cytotoxic potential of the quinones was evaluated against peripheral blood mononuclear (PBMC) and V79 cells. Additionally, the chemical reactivity of Rh(II) aza-vinyl carbenes generated in situ from these triazoles was studied. These compounds could provide promising new lead derivatives for more potent anticancer drug development.
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