4.4 Article

Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex

期刊

CHEMISTRYSELECT
卷 2, 期 1, 页码 230-240

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201600957

关键词

Antibacterial; Antifungal; Oxime; Palladium( II); complex; SEM study

资金

  1. Science & Engineering Research Board (SERB), DST, New Delhi, India under its Empowerment and Equity Opportunities for Excellence in Science Scheme [SB/EMEQ-029/2013]
  2. NSFC [21171109, 21271121, 21571118]
  3. SRFDP [20111401110002, 20121401110005]
  4. Natural Science Foundation of Shanxi Province of China [2010011011-2, 2011011009-1]
  5. Shanxi Scholarship Council of China [2012-004]

向作者/读者索取更多资源

This work delineates with the development of a novel oxime based palladium complex as a promising antimicrobial agent. A novel oxime based ligand, 3-[(2-hydroxy-naphthalen-1-ylmethylene)-hydrazono]-butan-2-one oxime (LH), has been employed to synthesize an orange, monomeric, diamagnetic palladium(II) compound, [Pd(L)(Cl)] (1) in moderate yield. LH is a monocondensate Schiff-base of 2,3-butanedionemonoxime monohydrazone and 2-hydroxy-1-naphthaldehyde in tetrahydrofuran. Both the ligand and its palladium compound have been characterized by spectroscopic and analytical techniques. The X-ray crystal structure of 1 reveals that the palladium center in [Pd(L)(Cl)] is nested in a distorted square-planar 'N2OCl'coordination environment. The electrochemical behavior of [Pd (L)(Cl)] in DMF shows a Pd(II)/ Pd(I) irreversible reduction couple. The in vitro antibacterial activity of [Pd(L)(Cl)] was tested against a good number of human pathogenic Grampositive and Gram-negative bacterial cell lines. The in vitro antifungal activity of the titled palladium compound was screened against several pathogenic fungal strains. The promising antimicrobial efficacy of the palladium compound was corroborated through SEM study.

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