Microwave-Assisted Highly Efficient Route to 4-Aminoquinoline-Phthalimide Conjugates: Synthesis and Anti-Tubercular Evaluation

Microwave assisted synthesis of 4-aminoquinoline-phthalimides was carried out in order to probe their anti-tubercular potential. Different conditions were screened both under conventional and microwave heating and the best results were obtained by microwave heating in DMSO at 160 degrees C for 2 min affording the desired 4-aminoquinoline-phthalimides in quantitative yields. Anti-tubercular evaluation against mc(2)6230 strain of Mycobacterium tuberculosis revealed 3e, having an octyl chain length as spacer, to be the most potent of the synthesized compounds exhibiting MIC99 of 13.7 mu M.