期刊
ACS SENSORS
卷 2, 期 7, 页码 857-875出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.7b00282
关键词
localized surface plastnon resonance; colorimetric sensor; nanoparticles; biosensor; biomarkers; point-of-care testing; molecular diagnostics; clinical diagnostics
资金
- National Natural Science Foundation of China [61405076, 21621003, 21327806]
- Fundamental Research Funds for the Central University [2016QNA5001]
- National Key Research and Development Program of China [2016YFA0203101]
Colorimetric detection of target analytes with high specificity and sensitivity is of fundamental importance to clinical and personalized point-of-care diagnostics. Because of their extraordinary optical properties, plasmonic nanomaterials have been introduced into colorimetric sensing systems, which provide significantly improved sensitivity in various biosensing applications. Here we review the recent progress on these plasmonic nanoparticles-based colorimetric nanosensors for ultra sensitive molecular diagnostics. According to their different colorimetric signal generation mechanisms, these plasmonic nanosensors are classified into two categories: (1) interparticle distance-dependent colorimetric assay based on target-induced forming cross-linking assembly/aggregate of plasmonic nanoparticles; and (2) size/morphology-dependent colorimetric assay by target-controlled growth/etching of the plasmonic nanoparticles. The sensing fundamentals and cutting-edge applications will be provided for each of them, particularly focusing on signal generation and/or amplification mechanisms that realize ultrasensitive molecular detection. Finally, we also discuss the challenge and give our future perspective in this emerging field.
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