期刊
ACS SENSORS
卷 2, 期 8, 页码 1128-1132出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.7b00383
关键词
biosensors; carbon nanotubes; electronic tongue; linear discriminant analysis; metal nanoparticle
资金
- National Institute of Environmental Health Sciences [R01ES019304]
- CAPES [99999.00278/2015-02]
Detection of malignant cells in tissue is a difficult hurdle in medical diagnostics and screening. Carbon nanotubes are extremely sensitive to their local environments, and nanotube-based field-effect transistors (NTFETs) provide a plethora of information regarding the mechanism of interaction with target analytes. Herein, we use a series of functionalized metal nanoparticle-decorated NTFET devices forming an array with multiple nonselective sensor units as the electronic tongue, sensing all five basic tastes. By extraction of selected NTFET characteristics and using linear discriminant analysis, we have successfully detected and discriminated between malignant and nonmalignant tissues and cells. We also studied the sensing mechanism and what NTFET characteristics are responsible for the variation of response between cell types, allowing for the design of future studies such as detection of malignant cells in a biopsy or the effects of malignant cells on healthy tissue.
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